MECP2 Duplication Syndrome is a rare neurogenetic disorder. It is usually found in males, although cases have been found in females. The syndrome is caused by a duplication of the MECP2 gene on the X chromosome and is usually inherited. Duplication of the MECP2 gene leads to an abundance of protein and causes symptoms such as intellectual disability, limited or absent speech, low muscle tone, and developmental delays. Symptoms often include frequent respiratory infections, autistic behaviors, seizures, progressive muscle spasticity, and feeding and gastrointestinal issues.